RAF Typhoon FGR4s have operated alongside France's air force in a joint strike against an subterranean weapons facility in Syria operated by the IS group, per a report from the UK's MoD.
The facility, located using intelligence, was thought to be housing weapons and explosive materials, the statement said, and was situated in hills just above the ancient city of Palmyra in the heart of Syria.
"Our aircraft utilized laser-guided Paveway IV weapons to target a several entry passages leading to the depot... preliminary assessments are that the strike was effective," officials stated.
There was no sign of any civilian casualties in the operation on Saturday evening and all the aircraft returned safely, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
Daesh - alternatively referred to as ISIS - established extremist governance over parts of Syria and Iraq before its territorial defeat in 2019.
"This action underscores our UK leadership, and commitment to work closely with allied nations, to stamp out any re-emergence of Daesh and their dangerous and violent ideologies in the area," the British Defence Secretary John Healey remarked.
UK warplanes have conducted patrols over Syrian airspace to "deter any attempted resurgence" of the group following its defeat at the battle of Baghuz in 2019, the authorities noted.
"I extend gratitude to every member of the UK armed forces involved in this strike for their expertise and their bravery," he said. "They were part of a great many British personnel deployed over Christmas and New Year. This operation, to take out terrorist threats who threaten our safety, highlights how our armed forces are always on standby, throughout the year, keeping Britain secure at home and strong abroad."
Last December, the American forces executed what it called a "major assault" targeting IS targets in the country, after an assault killed two US servicemembers and a civilian interpreter in the Palmyra area.
The U.N. estimates Islamic State still maintains an estimated 5,000 to 7,000 combatants in both countries.